NR3C1 and Alzheimer disease: For example, differential methylation of HPA axis genes such as dehydrogenase HSD11B1, glucocorticoid receptor NR3C1, and chaperone FKBP5 has been shown to be associated with environmental and social stressors such as childhood trauma, SES, and discrimination, as well as diseases such as hypertension, cancer, AD, and depression (Argentieri et al., 2017).