As shown by the Kaplan–Meier (KM) curve, there was a close relationship between the expression of WIPI3 and the overall survival of HCC patients that the high expression of WIPI3 caused significantly poor overall survival (P < 0.01), especially in 3–4 months (Figures 2B,C). The gene discussed is WDR45B; the disease is hepatocellular carcinoma.