CTLA4 and neoplasm: Besides HLA-G and ILT-2, additional IC molecules such as programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte-associated protein (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), and CD95 are associated in tumor-driven immune escape mechanisms acting locally at the tumor site or systemically in the peripheral blood (24–26).