Similarly, Dumont et al. (43) have demonstrated that CD8+ tumor infiltrating lymphocytes (TIL) expressing ILT-2 showed a higher cytotoxicity and IFNγ production compared to their ILT-2 negative or PD-1 expressing counterparts and that cytotoxicity of ILT-2 positive TIL, but not that of ILT-2 negative or PD-1 positive TIL could be inhibited by HLA-G. The gene discussed is HLA-G; the disease is neoplasm.