CD8A and Zika virus infectious disease: Given the neurotropism of ZIKV and the fact that a fraction of postnatal ZIKV infections in humans may result in various forms of neuropathology including fatal encephalitis (9, 10, 28), we found it pertinent to determine whether CD8 T cells could contribute significantly to antiviral protection in the CNS and if that were the case, what are the factors deciding the disease outcome.