CXCR3 and infection: Interestingly, those differences became insignificant by day 5 post i.c. In combination with the viral titers data on the CNS of CXCR3-deficient mice (Figure 8B), it seems that failure of ZIKV-specific CD8 T cells to be rapidly recruited to the site of infection favors ZIKV replication, and, even if numbers of recruited ZIKV-specific CD8 T cells matched WT levels by day 5 post i.c, the course of the infection was already determined by the early impairment.