RORA and hyperinsulinemic hypoglycemia, familial, 4: To demonstrate that the weight loss observed is specifically due to the deletion of Rora in myeloid cells, and not an off-target effect of disrupting the Rora gene, Rorafl/flIL-7RaCre/+ mice—a commonly used mouse to model ILC2 deficiency (29, 30)—were placed on HFD and used as an additional strain where Rora has been conditionally deleted in a specific cell type.