Importantly, the proportions of splenic Tem/rm CD8+ cells were not affected in the absence of March1 (Supplementary Figure S3D), indicating that the loss of March1 induces a specific enrichment of AT CD8+ T cells with an effector/resident memory phenotype, consistent with exacerbated obesity-induced IR in March1 KO mice and KO→WT BMCs. The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.