To verify if the exacerbated obesity-induced IR in March1 KO mice is related to the role of March1 in immune cells, we generated BMCs in which BM cells from WT or March1 KO mice were transferred to lethally irradiated WT recipients to generate WT→WT and KO→WT mice, respectively. The gene discussed is MARCHF1; the disease is obesity due to melanocortin 4 receptor deficiency.