Several studies have demonstrated altered levels of CHDP cathelicidin and calprotectin (a complex of subunits S100A8 and S100A9) in various chronic inflammatory diseases including rheumatoid arthritis (RA), chronic obstructive pulmonary disease (COPD), asthma, inflammatory bowel disease (IBD) and atherosclerosis (3–12). This evidence concerns the gene S100A8 and rheumatoid arthritis.