Thus, in this scenario, we speculate that lymphodepletion is able to contribute to effective anti-tumor immunity because, in addition to be critical to eliminate immune-suppressive cells (i.e., MDSCs, TAM, TEX, and Tregs) and decrease the metabolic competition in the TME for IL-7, IL-15, and nutrients, it bears the potential to support both ACT TM and possibly also endogenous TN and TM. Here, IL15 is linked to neoplasm.