Although in several instances the cellular and molecular mechanisms at the base of the synergistic effect need further investigation, bystander T memory cells were frequently found within the tumor infiltrates, (180) suggesting that pre-existing memory cells, unrelated to the cognate tumor-associated Ag targeted by TILs or TCR/CAR T cells, might contribute to anti-tumor immunity in ACT settings (Figure 3). Here, RENBP is linked to neoplasm.