Compared with osteoarthritis patients, the expression levels of miR-150-5p in the serum, synovial tissues, and fibroblast-like synoviocytes (FLS) of RA patients were significantly decreased, whereas the expression levels of matrix metalloproteinase (MMP) 14 and vascular endothelial growth factor (VEGF) were increased. The gene discussed is VEGFA; the disease is rheumatoid arthritis.