There are many ways in which anti-PLP antibodies, particularly those targeting epitopes on the extracellular surfaces of oligodendrocytes or myelin, could potentially have an impact in MS, including mechanisms such as complement-mediated lysis, antibody mediated cell cytotoxicity, modulation of cell architecture, opsonization of myelin or myelin debris leading to increased activation of phagocytic cells (19). Here, PLP1 is linked to myeloid sarcoma.