In autoimmune diseases, the induced B-cell subpopulation is characterized by CD1d up-regulation, and the up-regulated CD1d can induce B-cell subpopulations to produce IL-10, promote antigen-specific regulatory T cell differentiation, and down-regulate inflammatory cascades associated with IL-1 upregulation and STAT3 activation (6). This evidence concerns the gene IL10 and autoimmune disease.