Studies on auto antibodies have improved our understanding of the role of B cells in the pathogenesis of immune-mediated diseases such as the appearance of oligoclonal IgG bands and deposition of IgG in the cerebrospinal fluid of MS, the presence of AQP4-IgG in NMOSD and antibodies against MOG in MOG-Ab associated disease. This evidence concerns the gene AQP4 and myeloid sarcoma.