Li et al. have reported that C3aR antagonist treatment could alleviate kidney damage in DKD rats induced by a high-fat diet and streptozotocin by inhibiting Wnt/β-catenin, TGF-β/smad3 signaling pathways, IKBα phosphorylation, and IL-6 release, to reduce inflammation and fibrosis in glomerular endothelial cells (53, 54). The gene discussed is C3AR1; the disease is diabetic kidney disease.