CF macrophages have been previously shown to have several deficits related to phagocytosis, including deregulated transient receptor potential cation channel subfamily V member 2 (TRPV2)-mediated calcium influx, (19) reduced Ezrin-mediated toll-like receptor-4 (TLR4) signaling (47), and reduced complement-mediated phagocytosis (28). This evidence concerns the gene TLR4 and cystic fibrosis.