This includes hypersecretion of mucus, release of epithelial-derived cytokines called alarmins [e.g., interleukin 25 (IL-25), IL-33, thymic stromal lymphopoietin], chemokines, and antimicrobial peptides, as well as uncontrolled proliferation and differentiation processes, altogether leading to functional [e.g., airway hyperresponsiveness(AHR)] and structural (e.g., airway remodeling) changes that represent characteristic features of asthma pathology (10). Here, IL25 is linked to airway hyperresponsiveness.