Further, the overexpression of chemokines IL-8, CXCL 16, and RANTES as well as L-selectin, and E-selectin in PG/PASH lesional skin may also lead to the increased neutrophil and monocyte infiltration (30) in HS lesional skin. Here, CXCL8 is linked to Pyoderma gangrenosum-acne-suppurative hidradenitis syndrome.