Moreover, mtDNA-mediated NLRP3 activation induces caspase-1-dependent IL-1β production and contributes to STZ (streptozotocin)-induced T1DM in a murine model, directly indicating a diabetogenic effect of NLRP3-caspase-1-IL-1β signaling (117). Here, CASP1 is linked to type 1 diabetes mellitus.