Studies find that the vesicles formed after enterovirus infection showed the features of autophagosomes, for example, the double-layer membrane structure of vesicles, the increase of esterified LC3, and the enrichment of cells with LC3 punctate location (Taylor and Kirkegaard, 2007; Wong et al., 2008; Yoon et al., 2008; Klein and Jackson, 2011; Alirezaei et al., 2012; Shi et al., 2015). Here, MAP1LC3A is linked to enterovirus infectious disease.