PLOD1 and endocrine system disorder: Emerging as an important contributor to PCOS, on the one hand, IR can promote the luteinizing hormone (LH) and androgen secretion, reduce the content of serum sex hormone binding protein and aggravate hyperandrogenemia and endocrine disorder, on the other hand, it also can directly induce abnormal follicular development and atresia, causing polycystic ovarian morphology (35, 36).