Importantly, Fife et al., identified a critical role for PD-1/PD-L1 in the response of T1D patients to anti-CD3 immunotherapy (22), suggesting that PD-1–PD-L1 interactions are part of a common pathway to selectively maintain tolerance within the pancreatic tissue and the draining lymph nodes possibly through induction of T cell exhaustion. This evidence concerns the gene CD274 and type 1 diabetes mellitus.