(a) Prevalence of autoimmune thyroid disorders and (b) associated non-autoimmune thyroid disorders in pediatric patients with TS, DS, KS, 22q11.2DS, WS, PWS, NS, and NF1 (c) possible underlying mechanisms involved in the pathogenesis of autoimmunity and (d) extrathyroidal autoimmune disorders associated with these syndromes. The gene discussed is NF1; the disease is autoimmune disease.