The hypoxia in the GBM tumor induces the expression of genes involved in tumor cell growth and angiogenesis like the signal transducer and activator of transcription 3 (STAT3), which triggers the synthesis of HIF-1α that subsequently induces activation of T-regulatory cells (Tregs) and the production of VEGF (111). The gene discussed is HIF1A; the disease is glioblastoma.