In PD, increased cytokine levels in response to cellular stress can lead to neuronal cell death whereas in GBM, cytokines like interleukins IL-1β, IL-6, and IL-8 released by the tumor cells, inhibit the immune response and allow the tumor cells to escape the eradication by the immune system (Figure 2B). The gene discussed is CXCL8; the disease is neoplasm.