MDM4 and central nervous system cancer: The mutant genes in this group included MGMT, IDH1, IDH2, 1p/19q, BRAF, TP53, CDKN2A, H3F3A, MDM2, ATM, EGFR, ALK, CDK4, ERBB2, MDM4, MET, NF1, PDGFRA, PTEN, ARID1A, BRCA1, CCNE1, FGFR1, KIT, KRAS, and PIK3CA. Based on Table 7, the characterizations of IDH mutations in the glioma included IDH1 mutation (p.R132H) and IDH2 mutation (p.R172K).