BDNF and schizophrenia: In order to evaluate whether modulation of cerebral demyelination could be a novel treatment target of schizophrenia, chronic administration of MK-801 was used to induce schizophrenia-like behaviors and possible cerebral demyelination by measuring MBP, and the effect and BDNF-related neuroprotective mechanism of quetiapine on the MK-801–induced schizophrenia-like behaviors and demyelination was investigated in mice in the present study.