Previous studies have shown that quetiapine attenuated the immobilization stress-induced decrease in expression of brain-derived neurotrophic factor (BDNF, a neuroprotective protein) (19), promoted neuroplasticity via the up-regulation of BDNF (20) in rat hippocampus, and modulated conditioned anxiety by affecting brain BDNF expression in Alzheimer’s transgenic mice (21). The gene discussed is BDNF; the disease is Anxiety.