TP53 and cleft palate: Based on the analysis of gene expression data (GSE42589) in DPSCS from GEO datasets, both MDM2 and P53 mRNA were detected in DPSCs from 13 samples, including 6 control samples and 7 non-syndromic cleft lip with or without cleft palate (NSCL/P) samples (Figure 2), which often accompanied by tooth agenesis.