Similarly, treatment with MCC950 attenuated mechanical allodynia in a rodent model of cancer-induced bone pain, and in oxaliplatin-induced peripheral neuropathy model and restored the increased expression levels of NLRP3, ASC, caspase-1 and IL-1β in spinal cord to basal levels (Wahlman et al., 2018; Chen et al., 2019). This evidence concerns the gene NLRP3 and cancer.