For example, emodin (30 mg/kg) significantly inhibited the expression of tumor necrosis factor-α (TNF-α) and the activation of NF-κB in the local myocardial infarction area of acute myocardial infarction (AMI) model mice, protected myocardial cell injury by inhibiting local inflammation, reduced the range of myocardial infarction induced by occluding the left anterior descending coronary artery in BALB/c mice in a dose-dependent manner (Wu et al., 2007). This evidence concerns the gene TNF and myocardial infarction.