Currently, it is generally believed that PTEN, as the main inhibitor of the PI3K/AKT signaling pathway, can negatively regulate the signaling pathway by dephosphorylating PIP3 to generate PIP2, which results in the downregulation of p-AKT, thus inhibiting the proliferation of cancer cells (Tay et al., 2011; Russell et al., 2018). The gene discussed is AKT1; the disease is cancer.