TNF and osteoporosis: This study found that Ext-epi can significantly improve the phenomenon of elevated levels of BMD, BMC, serum osteocalcin, and tumor necrosis factor-αlevels in OP rats, and can also significantly reduce the level of estradiol in the body, indicating that the occurrence of osteoporosis in OP rats may be closely related to the decrease of estradiol content in the body.