TNF and Sepsis: It has been demonstrated that the most important mediators for orchestrating this imbalance during sepsis are cytokines (Levi et al., 1997), such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-α (TNF-α), but also denatured DNA and cationic proteins, such as histones, released from damaged cells (McDonald et al., 2017)[21].