An unbalanced ω-6/ω-3 ratio is highly proinflammatory in terms of arachidonic acid metabolism and IL-1β production contributes to the prevalence of atherosclerosis and obesity (Simopoulos, 2008), which may be a potential factor for increased risk of stones in atherosclerosis patients and obese people. Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.