However, antagonizing 5-LO signaling arrests ECs from dividing in culture and chronic hypoxia induces abnormal EC proliferation in a 5-LO-dependent fashion, implicating that 5-LO expression is required for EC mitosis (Walker et al., 2002; Porter et al., 2014). Additionally, 5-LO is expressed in the nuclei of a number of cancer stem cells; 5-LO causes ECs lack of BMPR2 signaling to transform into a cancer stem cell-like phenotype, and targeting 5-LO suppresses the adverse growth responses (Romano et al., 2001; Chen et al., 2009a; Chen et al., 2009b; Roos et al., 2014; Tian et al., 2019). This evidence concerns the gene ALOX5 and cancer.