A recent study demonstrates a pivotal function of LTB4/BLT1 signaling for the tumor immune suppression of CD8+ T cells: CD8+ T cells depletion enhances tumor growth in wild-type but not in BLT1−/− mice, implicating the importance of BLT1 in CD8+ T cells cancer immunity (Sharma et al., 2013). The gene discussed is CD8A; the disease is cancer.