MAPK1 and colonic neoplasm: LTB4 directly stimulates colon cancer cell growth and survival through a BLT1/ERK-dependent pathway in vitro; it induces the proliferation of human pancreatic cancer cells through MAPK/ERK and PI3K/Akt-dependent pathways; both LTB4 and CysLTs prompt the expansion of CD24+CD90+ metastasis-initiating cells (Tong et al., 2005; Ihara et al., 2007; Wculek and Malanchi, 2015).