In contrast, dying tumor cells can stimulate the production of TNF-α, epidermal growth factor (EGF), IL-6, and Wnt ligands, which in turn recruit myeloid cells and fibroblasts to the local TME, serving as anti-cell death signals and decreasing the efficacy of anti-tumor therapies (Labi and Erlacher, 2015). The gene discussed is IL6; the disease is neoplasm.