Many anti-inflammatory agents, including NSAIDs (nonsteroidal anti-inflammatory drugs) which inhibits cyclooxygenase (COX-1, COX-2, or both) or both COX and 5-LO, as well as, specific inhibitors of 5-LO and leukotriene signaling, have demonstrated promising results in interfering with the tumor microenvironment (Cruz-Correa et al., 2002; Baron, 2003; Rayburn et al., 2009; Wong, 2019). The gene discussed is ALOX5; the disease is neoplasm.