For example, Lu and co-workers identified 100 mg·kg-1 of EO as the most effective dose that produced significant decrease in severity of bronchitis symptoms, less inflammatory cells infiltration, and reduced airway mucin secretion in rat chronic bronchitis caused by lipopolysaccharide (LPS) (Lü Xiaoqin et al., 2004). The gene discussed is MUC5AC; the disease is bronchitis.