F2R and colorectal adenocarcinoma: Next, we also investigated the impact of AT1R-PAR1 functional interaction on the Gαq/inositol phosphate pathway in the human epithelial colorectal adenocarcinoma cells (HT-29) previously reported to express endogenous AT1R (Ozeki et al., 2013; Wang et al., 2013) and PAR1 (Darmoul et al., 2004).