Also, the Gαq/inositol phosphate pathway was investigated in both HEK293 cells transiently expressing the receptors as well as in the human epithelial colorectal adenocarcinoma cells (HT-29) reported to express endogenous AT1R (Ozeki et al., 2013; Wang et al., 2013) and PAR1 (Darmoul et al., 2004). This evidence concerns the gene AGTR1 and colorectal adenocarcinoma.