AGT and hypertensive disorder: The AngII/thrombin interplay has been evidenced in different physiological (platelet aggregation, vasoconstriction, salt and water reabsorption, proliferation of vascular muscle cells, and chemotaxis) and pathophysiological (atherosclerosis, restenosis, hypertension, and glomerular diseases) models (Weber, 1994; Polevaya, 1996; Kim and Iwao, 2011; Hasan et al., 2019).