Loss of SMP30 is associated with kidney damage in several mouse models (Yumura et al., 2006; Kondo et al., 2013; Miyata et al., 2013; Okada et al., 2015; Kondo and Ishigami, 2016; Yamauchi et al., 2016; Dutta et al., 2019). This evidence concerns the gene RGN and Nephropathy.