Besides, at high concentrations, IL-6 binds to sIL-6R (soluble form of IL-6 receptor) and gp130, and activates JAK-STAT3 pathway in cells that do not express mIL-6R which again induces cytokine storm by releasing several cytokines and chemokines (e.g., VEGF, IL-6, MCP-1/CCL2, IL-8, etc.), and by reducing E-cadherin production that leads to ARDS (Magro, 2020; Ragab et al., 2020). This evidence concerns the gene CCL2 and acute respiratory distress syndrome.