TP53 and neoplasm: In previous literature, GA induced tumor cells apoptosis is closely associated with mitochondria dependent endogenous apoptosis pathway (Wang et al., 2016; Gu et al., 2018), so we decided to detect the expression of mitochondrial apoptosis pathway related markers (Bcl-2, Bax, P53, Caspase-3, and Cyt-c).