DNMT1 and colorectal neoplasm: Human colorectal tumors have lower levels of PPARA mRNA and protein than nontumor tissues and loss of PPAR-α promotes colon carcinogenesis by increasing DNMT1 methyltransferase mediated methylation of p21 and PRMT6 methyltransferase mediated methylation of p27 (Luo et al., 2019).