Many of the oncogenic pathways associated with CRC such as MAPK and PI3K/AKT/mTOR converge on the translation machinery and it has been shown that global alterations in translation have an important role in cancer progression to metastasis, since apoptosis and protein synthesis is affected mainly at the level of translation (Provenzani et al., 2006). Here, PIK3CA is linked to colorectal carcinoma.