Although level of translation is globally decreased in hypoxic tumor tissue, the mRNA of various factors that respond to hypoxia such as HIF-1α, CREB, NF-κB, cyclin-D1, c-MYC, VEGF, and others are preferentially translated in cancer cells, thereby promoting prosurvival, proproliferative and proangiogenic phenotype (Koritzinsky et al., 2006). The gene discussed is CREB1; the disease is cancer.