PRDX2 and cancer: Peroxiredoxins-2 and -6 are both thiol-specific peroxidases that catalyze the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, so their downregulation could contribute to the elevated levels of these ROS which could abrogate specific induction of selective growth of tumor cells by protecting them against oxidative stress, as has been observed in some cancers (Stresing et al., 2013).