Kim et al. (2018) established a mouse model of DN induced by a high-fat diet and STZ after unilateral nephrectomy. The results showed that extracts of A. manihot (100 mg/kg [i.g.] for 35 days) markedly reduced the levels of plasma creatinine, BUN, and urinary albumin. Moreover, the kidney/body weight ratio also increased in mice with DN in comparison with control mice (Kim et al., 2018). Here, ALB is linked to liver dysplastic nodule.