Similarly, the results of an in vivo study proved that TEA at a dose of 1.5 g/kg (i.g.)significantly reduced proteinuria and low serum albumin levels, alleviated lesions of the renal tubules, and inhibited the expression of ROS, ERK1/2, and NLRP3 inflammasome proteins in the renal tubules of rats with doxorubicin-induced nephropathy in comparison with a doxorubicin model group (Li et al., 2019), which indicates that TEA protects renal tubular cells against doxorubicin-induced injury by suppressing the ROS-ERK1/2-NLRP3 inflammasome signaling pathway both in vitro and in vivo. This evidence concerns the gene MAPK3 and Nephropathy.