SOD1 and major depressive disorder: In addition, TFAM (at doses of 25, 50, and 100 mg/kg [i.g.] for 24 days) significantly increased the crossing and rearing scores in an open-field test; suppressed increases in the viscosity of whole blood, as well as plasma, at high, moderate, and low shear rates; decreased the deformation of erythrocytes; enhanced the activities of SOD and GPx; and decreased the MDA content in the brains of rats with poststroke depression in comparison with fluoxetine (1.8 mg/kg) (Hao et al., 2007).