Glucose transporters (GLUTs) deficiency and glucose deprivation have been shown to trigger tau hyperphosphorylation and cognitive impairment (Liu et al., 2008; Lauretti and Pratico, 2015; Lauretti et al., 2017), which suggests a strong relationship between hyperphosphorylated tau levels and glucose metabolism in AD progression. This evidence concerns the gene MAPT and Cognitive impairment.