Researches showed the lower levels of these GLUTs are associated with more severe AD pathology (An et al., 2018), and the ablation of GLUT3 and GLUT4 in mouse brain triggered glucose uptake deficits and synaptic deficits (Ashrafi et al., 2017; Reno et al., 2017). The gene discussed is SLC2A4; the disease is Alzheimer disease.