DLG4 and Mental deterioration: In correlation with early onset of cognitive decline, we observed significant decrease of cortical synapse markers Syn1 and PSD95 in 2-month-old 5xFAD offspring exposed to antenatal hypoxia, which occurred in somatosensory and prefrontal cortices of 5xFAD mice at 6 months (Crowe and Ellis-Davies, 2014).