It is proposed that inflammation, originated from CP, might add to the inflammatory pool in the serum by contributing several pro-inflammatory mediators, such as C-reactive protein, interleukin (IL)-1, IL-6, and TNF-α, which cause cell apoptosis, tumor genesis, neuro-inflammation, and a systemic immune response (Rapone et al., 2019; Wang et al., 2019). Here, TNF is linked to neoplasm.