GATA4 and cancer: Supplementary Figure S5 provides data on the top gene-to-pathway (Supplementary Figure S5A) and pathway-to-pathway interactions (Supplementary Figure S5B), with potential implications and associations with the appearance of polyphasic activity. The pathways revealed are implicated in various metabolic paths such as Histidine metabolism, bile secretion, cancer such as colorectal cancer, ribosome formation, and one carbon pool by folate. In the enrichment analysis HTR2C gene was found to be implicated with Serotonin receptors-2 and Elk-SRF/GATA4 signaling.