Another astrocytic mechanism that can lead to epilepsy involves the dislocation of AQP4 water channels and reduced expression of Kir channels in astrocytes, which affect K+ clearance and enhance the propagation of seizures (Lee et al., 2004; Binder et al., 2006; Seifert et al., 2006; Szu et al., 2020) These findings demonstrate the importance of neuron-glia communication mechanisms when considering new therapeutic targets for epilepsy. This evidence concerns the gene AQP4 and epilepsy.