AD, the most prevalent form of dementia worldwide (Ferri et al., 2005), is a progressive neurodegenerative disorder characterized by the build-up of β-amyloid (Aβ) plaques, intracellular neurofibrillary tangles (NFTs) with hyper-phosphorylated tau and activated glial cells surrounding senile plaques (Morley et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.