APP and Alzheimer disease: In AD research, NLRP3-contained inflammasome attracted great attention, as it is activated in AD brain and potentially mediates microglial inflammatory responses, exaggerates Aβ and Tau protein aggregation in APP or Tau-transgenic mice (Heneka et al., 2013; Venegas et al., 2017; Ising et al., 2019; Stancu et al., 2019).