Despite reports of peripheral phenotypes, most notably within the kidney and lung (Tong et al., 2010; Herzig et al., 2011), LKO mice, and even wild-type (WT) mice subject to acute LRRK2 knock-down (Volta et al., 2015a), do not present with overt PD-like phenotypes, and generally seem normal in terms of behavior and neurophysiology (Andres-Mateos et al., 2009; Lin et al., 2009; Hinkle et al., 2012; Beccano-Kelly et al., 2014, 2015; Volta et al., 2015a). Here, LRRK2 is linked to Parkinson disease.