Also, a recent study found that triggering receptor expressed on myeloid cells 2 (TREM2) is necessary for synaptic pruning during development (Filipello et al., 2018), which is especially interesting since TREM2 variants have been linked to increased risk for AD and FTD (Guerreiro et al., 2013a,b; Filipello et al., 2018). Here, TREM2 is linked to frontotemporal dementia.