Additionally, while AD brain homogenate only seeded intraneuronal tau pathology, CBD and PSP brain homogenate led to oligodendrocytic, astrocytic and neuronal tau pathology, supporting the idea that different strains of the tau protein found in different tauopathies have unique cell-type specific pathogenic properties (Narasimhan et al., 2017). Here, MAPT is linked to Alzheimer disease.