Glial tau pathology is not usually associated with AD, therefore, it has been suggested that this effect is likely due to aging (such as that found in aging-related tau astrogliopathy or ARTAG), although other tauopathies are characterized by glial tau pathology (Schultz et al., 2004; Lace et al., 2012; Kovacs et al., 2016). This evidence concerns the gene MAPT and Alzheimer disease.