Also, tufted astrocytes in PSP and astrocytic plaques in CBD are labeled by antibodies specific to the carboxyl-terminus and the middle portion of the tau protein but are not detected by antibodies against the amino-terminus, suggesting that a portion of the amino-terminus of the tau protein may be missing in astrocytic tau pathology (Ferrer, 2018). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.