These observations with our present data, particularly the high proportion of parvalbumin and calbindin positive cells that were dysmorphic and cytomegalic in cortical tubers, tend to suggest that TSC lesions are mosaics lesions generated from different classes of progenitors, from pallium and subpallium, a feature that should not be surprising for a multisystemic pathology like TSC originated in most of the reported cases by germ-line TSC2 or TSC1 mutations. Here, TSC1 is linked to tuberous sclerosis.