Tuberous sclerosis (TSC) is a systemic, autosomal dominant genetic disorder caused by mutations of TSC1 or TSC2 genes (Dragoumi et al., 2018; Hasbani and Crino, 2018) that result in a constitutive activation of mTORC1 disturbing subsequently cellular differentiation, proliferation, and migration early in development. The gene discussed is TSC2; the disease is tuberous sclerosis.