It has been well documented that the appearance of peripheral neuropathy in type 1 and type 2 diabetes mellitus is strongly associated with increases in inflammatory biomarkers, including C-reactive protein, TNF-α, and IL-6 (Hussain et al., 2013; Zhu et al., 2015; Ge et al., 2016). This evidence concerns the gene TNF and type 2 diabetes mellitus.