Western blot experiments showed in the presence of sh-LINC02418, protein level of cleaved-Caspase 9 and cleaved-Caspase 3 in CRC cells was significantly increased while BCL2 expression was inhibited, indicating silence of LINC02418 could improve cell apoptosis and reduce colon cancer cells growth (Fig. 5a). The gene discussed is CASP3; the disease is malignant colon neoplasm.