HAVCR2 and acute lymphoblastic leukemia: Moreover, using this novel construct, namely TRAC-CAR, in the treatment of precursor-B acute lymphoblastic leukemia NALM-6 mice models showed a significant decrease in expression of three important exhaustive markers (PD-1, LAG3, and TIM3) from 50% in routine CARs to below 2% in this redesigned version [108].